Research
From American Academy of Periodontology
Gene therapy offers hope for gum disease
A study published in the Journal of Periodontology reported an encouraging step toward regenerating the structures that periodontal disease destroys. University of Michigan researchers, led by Dr. William Giannobile, used a tissue-engineering approach in animals: a bone-stimulating gene was delivered into skin cells, and those engineered cells were transplanted into large periodontal defects around the teeth.
The result was regeneration of tooth-supporting structures — jawbone, periodontal ligament and the root's protective cementum — something no existing therapy could predictably achieve. Human trials would be the next step, but the Academy greeted the work as a milestone for a disease that quietly affects millions of Americans and remains a leading cause of tooth loss.